Pyogenic granuloma is one of the inflammatory hyperplasias seen in the oral cavity. This term is misnomer because the lesion is unrelated to infection and in reality arises in response to various stimuli such as low grade local irritation, traumatic injury or hormonal factors is also known as Non Specific Conditioned Enlargement . It predominantly occurs in the second decade of life in young females, possibly because of the vascular effects of female hormones. It also develops in up to 5% of pregnancies due to hormonal influence. Clinically, oral pyogenic granuloma is a smooth or lobulated exophytic lesion manifesting as small, red erythematous papules on a pedunculated or sometimes sessile base, which is usually hemorrhagic. The surface ranges from pink to red to purple, depending on the age of the lesion. Although excisional biopsy is the treatment of choice for it, other treatment modalities such as the use of lasers, flash lamp, pulsed dye laser, cryosurgery, intralesional injection of ethanol have been proposed. We report here a case series involving three of Pyogenic Granuloma attributed to gingival irritation and inflammation, their clinical features, investigations carried out and the treatment provided.