Use of PRF in bony regeneration surgery

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Published: Wednesday, 18 March 2015 13:19 Written by 

Platelet-rich fibrin (PRF) can be regarded as an autologous healing biomaterial, incorporating leukocytes, platelets and the majority of the molecules that take part in the tissue healing processes within the autologous fibrin matrix. In this article, the clinical and biological aspects of the action of PRF on bone regeneration in the various fields of application in oral surgery are analyzed. The search for protocols promoting hemostasis and healing is a recurrent problem in all surgical disciplines. Thanks to the work of Lynch1, there has been interest in growth factors in peri-implantology, and Marx in 1998 published the first studies on the use of platelet growth factors in the form of platelet-rich plasma.2,3 Since then, platelet aggregates of biological quality high in cytokines have been used in a large number of clinical situations. In periodontal, peri-implant and maxillofacial surgery, platelet aggregates play a role as biological bonding agents between the different components of a bone or gingival graft and act as a protective gel for the operation site, similar to the autologous fibrin glues used in the past4–12 where the fibrinogen was activated by the action of calcium and thrombin. In 2004, a new protocol was suggested in France for concentrating growth factors as an alternative to PRP: platelet-rich fibrin or PRF.13

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