Guided bone regeneration using a high-density titanium-reinforced PTFE Membrane

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Published: Wednesday, 18 September 2013 11:09 Written by 


Extraction site grafting without primary closure. A 55 year-old female presented for implant placement in a recent extraction site. Surgical exposure revealed fibrous healing at the buccal and coronal aspect of the site, requiring augmentation simultaneous with implant placement (Fig 1 and Fig 2) to regenerate the buccal bone contour.

A high-density, titanium-reinforced PTFE membrane in a  ingle tooth configuration (Cytoplast® Ti-250 Anterior Narrow) was trimmed to fit over the defect and then curved over an instrument handle to provide three-dimensional support and stability (Fig 3a and Fig 3b). Mineralized bone allograft was placed into the defect (Fig 4) and covered with the membrane. The membrane is trimmed to remain 1.0 mm away from the roots of the adjacent teeth, and to extend 3 to 5 mm beyond the defect margins (Fig 5). Primary closure was achieved using a 3-0 PTFE suture (Fig 6). After four months of uneventful healing, the soft tissue covering the membrane appears healthy prior to implant exposure and abutment placement (Fig 7). Four months after implant placement, the PTFE barrier remains covered with mucosa and regeneration of hard tissue is evident radiographically (Fig 8). Exposure of the barrier is accomplished using a u-shaped incision with apical advancement of the keratinized gingiva ( Fig 9).

 The high-density PTFE membrane is easily removed through a conservative incision due to limited soft tissue ingrowth into the barrier (Fig 10). Clinically, restoration of the full width of keratinized gingiva was observed at the time of abutment placement (Fig 11).  Three months after implant placement, the restorative components were placed and the implant was restored with a porcelain fused to metal restoration (Fig 12 and Fig 13).


This case report demonstrates the successful augmentation of a localized defect involving the entire buccal plate of a recent extraction site. The use of a titanium reinforced, highdensity PTFE membrane provides predictable space-making and regenerative function without the risks associated with highly porous, expanded PTFE devices such as Gore-Tex®.



1. Preoperative view. To maximize the result of ridge preservation procedures, techniques designed to minimize trauma to the alveolar bone, such as the use of periotomes and surgical sectioning of ankylosed roots should be considered.


2. All soft tissue remnants should be removed with sharp curettage. Special care should be taken to remove all soft tissue at the apical extent of the socket of endodontically treated teeth. Bleeding points should be noted on the cortical plate. If necessary, decortication of the socket wall should be done with a round bur to improve blood supply.


3. A subperiosteal pocket is created with a micro periosteal elevator or small curette, extending 3-4 mm beyond the socket margins on the palatal and the facial aspect of the socket. In the esthetic zone, rather than incising and elevating the interdental papilla, it is left intact and undermined in a similar fashion. The Cytoplast d-PTFE membrane will be tucked into this subperiosteal pocket.


4. Particulate graft material can be placed into the socket with a syringe or with a curette. Ensure that the material is evenly distributed throughout the socket. However, the particles should not be densely packed to preserve ample space for blood vessel ingrowth.


5. The Cytoplast d-PTFE membrane is trimmed to extend 3-4 mm beyond the socket walls and then tucked subperiosteally under the palatal flap, the facial flap and underneath the interdental papilla with a curette. The membrane should rest on bone 360° around the socket margins, if possible. Note that minimal flap reflection is necessary to stabilize the membrane.


6. Ensure that there are no folds or wrinkles in the membrane and that it lies passively over the socket. To prevent bacterial leakage under the membrane, take care to avoid puncturing the membrane, and do not overlap two adjacent pieces of membrane material.


7. The membrane is further stabilized with a criss-cross suture. Alternatively, interrupted sutures may be placed. The sutures are left in place for 10 to 14 days.


8. The membrane is removed, non-surgically, in 21 to 28 days. Sockets with missing walls may benefit from the longer time frame. Topical anesthetic is applied, then the membrane is grasped with a tissue forceps and removed with a gentle tug.


9. Studies have shown that by 21-28 days there is a dense, vascular connective tissue matrix in the socket and early osteogenesis is observed in the apical 2/3 of the socket.


10. Immediately following membrane removal, a dense, highly vascular, osteoid matrix is observed. The natural position of the gingival margin has been left intact because primary closure was not necessary. The dense PTFE membrane has contained the graft material and prevented epithelial migration into the socket.


11. The socket at 6 weeks. Keratinized gingiva is beginning to form over the grafted socket. The natural soft tissue architecture is preserved, including the interdental papillae. New bone is beginning to form in the socket.

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