Salvatore Sauro, Professor of Biomaterials and Minimally Invasive Dentistry at University CEU Cardenal Herrera (CEU-UCH) in Valencia (Spain), has been working on an impressive research program where the main objective is the development of bioactive restorative and/or preventive materials with potential regenerative properties for dental tissues.
Professor Sauro has more than 15 years of experience in dental adhesion, preventive and biomaterials research with more than 60 scientific articles in international peer-review journals, 1 international patent and 1 Brazilian patent. He has a wide international collaboration network with several centers of research and dental school around the world. His international and strong scientific reputation has allowed him to become visiting professor at the Federal University of Ceará, Brazil, where he is leading a research project for the development of innovative restorative materials with bioactive and anti-bacterial
Salvatore Sauro, directed a paper that was published in the Journal of Dental in collaboration with international researchers from Finland, Brazil, United States and United Kingdom. The research report has demonstrated how the use of zoledronic acid which is employed as a treatment for osteoporosis and bone cancer , in combination with bioactive ion-releasing resin-based restorative materials used as dental adhesive, reduces the degradation of dentin collagen and promotes remineralisation at the resin-dentine interface.
Zoledronic acid is a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density and decreasing the amount of calcium released from the bones into the blood, so it’s used in many ways as treating Pajet’s Disease, also used to prevent or treat osteoporosis in women who have undergone menopause, and applied in cancer chemotherapy to treat bone damage caused by multiple or by cancer that began in another part of the body but has spread to the bones. But For the first time Zoledronic acid has been tested in combination with bioactive resin-based adhesive systems and applied in restorative dentistry.
. The research performed by Professor Sauro and his team showed that the remineralisation properties of bioactive ion-releasing resin-based materials can be potentiated when they are employed in combination with biomimetic phosphoproteins' analogues of dentine mineralization such as Zoledronic acid. It is well known that resin-hybridized dentin can be affected by the proteolytic action of host-derived matrix metalloproteinases present within the dentine matrix, also in the absence of bacterial enzymes.
However, collagen degradation within incompletely infiltrated hybrid layers may be prevented by biomimetic remineralization of the denuded collagen fibrils within the resin-dentine bonding interface.